Welcome
The Vaccine and Gene Therapy Institute at Oregon Health & Science University has assembled a multidisciplinary team of scientists to respond to serious viral disease threats, including AIDS, chronic viral infection-associated diseases, newly emerging viral diseases and infectious diseases of the elderly. Our programs are intended to span the continuum between basic and clinical science, in which discoveries are rapidly advanced from the level of molecular and cellular biology through animal models and ultimately into clinical testing. Learn more
VGTI Seminar Series
Recent publications
J Acquir Immune Defic Syndr. June 1, 2025
Leronlimab Treatment for Multidrug-Resistant HIV-1 (OPTIMIZE): A Randomized, Double-Blind, Placebo-Controlled Trial
Sci Rep. May 26, 2025
HaloPROTAC3 does not trigger the degradation of the halotagged parasitophorous vacuole membrane protein UIS4 during Plasmodium liver stage development
Front Immunol. May 21, 2025
Neuroinflammation associated with proviral DNA persists in the brain of virally suppressed people with HIV
Commun Med (Lond). May 17, 2025
Immune imprinting and vaccine interval determine antibody responses to monovalent XBB.1.3 COVID-19 vaccination
Pediatrics. May 1, 2025
Monoclonal Antibodies for Pediatric Viral Disease Prevention and Treatment
Cell Genom. April 8, 2025
Enhanced interpretation of immune cell phenotype and function through a rhesus macaque single-cell atlas
Pediatrics. April 3, 2025
Monoclonal Antibodies for Pediatric Viral Disease Prevention and Treatment
Viruses. Mar 26, 2025
Analysis of Factors That Regulate HIV-1 Fusion in Reverse
J Infect Disease. Mar 17, 2025
Impact of Dolutegravir Plus Lamivudine as First-line Antiretroviral Treatment on the Human Immunodeficiency Virus Type 1 Reservoir and Inflammatory Markers in Peripheral Blood
PLoS Negl Trop Dis. March 17, 2025
Development of a virulent O’nyong’ nyong challenge model to determine heterologous protection mediated by a hydrogen peroxide-inactivated chikungunya virus vaccine
Sci Transl Med. March 12, 2025
The pentameric complex is not required for congenital CMV transmission in seronegative rhesus macaques
J Immunol. February 27, 2025
Glycoprotein L-deleted single-cycle rhesus cytomegalovirus vectors elicit MHC-E-restricted CD8+ T cells that protect against SIV
bioRxiv. February 27, 2025
Comparative Molecular, Innate and Adaptive Impacts of Chemically Diverse STING Agonists
Lancet Microbe. February 27, 2025
Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection
bioRxiv. February 22, 2025
Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates
iScience. Feb 11, 2025
Contribution of intact viral genomes persisting in blood and tissues during ART to plasma viral rebound in SHIV-infected rhesus macaques
J Virol. January 31, 2025
Third intracellular loop of HCMV US28 is necessary for signaling and viral reactivation
Nat Commun. January 31, 2025
Rhesus Cytomegalovirus-encoded Fcy-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity
J Virol. January 21, 2025
Generation of chimeric forms of rhesus macaque Rhadinovirus expressing KSHV envelope glycoproteins gH and gL for utilization in an NHP model of infection
PLoS Pathog. January 16, 2025
Kaposio’s sarcoma-associated herpesvirus (KSHV) gB dictates a low-pH endocytotic entry pathway as revealed by a dual-fluorescent virus system and a rhesus monkey Rhadinovirus expressing KSHV gB
Nat Immunol. January 16, 2025
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
Ways to Give
Donate to Vaccine and Gene Therapy Institute.
VGTI offers two options and account to consider when donating that serve differing purposes:
The VGTI Support Foundation Fund
Gifts to the VGTI Support Foundation Fund provides vital support that allows us find cures for life threatening infectious diseases. These funds help us to have necessary resources and create and conduct innovative infectious disease research studies, leading to the development of vaccines and cures.
The Jay Nelson Memorial Fund
Gifts to the Jay Nelson Memorial Fund supports providing education and learning opportunities for our current up and coming scientists with a focus on Herpesvirus.
Biographical Feature:
In memoriam Jay A. Nelson (1948–2024)
Your Gift Brings Hope, Please support our mission in memory of Jay Nelson. Your generosity will help support education and learning opportunities for our current up and coming scientists with a focus on Herpesvirus. Click to Donate
The VGTI Support Foundation Fund
Donate to VGTI
Your gifts help provide vital resources to conduct innovative research and more.
COVID-19 Efforts - Building a COVID Testing Lab