Lisa A. Karstens, Ph.D. (she/her)
- Associate Professor of Medical Informatics and Clinical Epidemiology, School of Medicine
- Biomedical Informatics Graduate Program, School of Medicine
Biography
Dr. Karstens is an Associate Professor at Oregon Health & Science University in the Departments of Medical Informatics and Clinical Epidemiology and Obstetrics and Gynecology. She is also the Co-Division Head of the Division of Bioinformatics and Computational Biology at OHSU. Her research interests broadly span using bioinformatics to understand complex human disease. Her current research focuses on using bioinformatic approaches to understand bladder disorders, with a specific focus on understanding how the human microbiome contributes to bladder health and disease.
While Dr. Karstens' research is interdisciplinary, her expertise is in bioinformatics- specifically microbiome, metabolomics, and neuroimaging analysis. She collaborates with clinicians and molecular biologists on a regular basis on a variety of projects.
Teaching and Mentoring
Dr. Karstens teaches Introduction to Programming for the Department of Medical Informatics and Clinical Epidemiology at OHSU, which focuses on understanding programming logic and is taught in Python. She mentors many types of students ranging from high school students to graduate students and medical fellows.
Education and training
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Degrees
- Ph.D., 2010, Princeton University
- M.B.I., 2013, Oregon Health & Science University
Areas of interest
- Microbiome
- Bioinformatics
- Women's Health
Publications
Selected publications
- Community profiling of the urinary microbiota: considerations for low-biomass samples. Karstens L, Asquith M, Caruso V, Rosenbaum JT, Fair DA, Braun J, Gregory WT, Nardos R, McWeeney SK. Nature Reviews Urology 2018 Oct 12. [Epub ahead of print] PMID: 30315209
- Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine. Nakamura YK, Janowitz C, Metea C, Asquith M, Karstens L, Rosenbaum JT, Lin P. Sci. Rep. 2017; 7, 11745. PMID: 28924192
- Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells. Benedek G, Zhang J, Ngyuyen H, Kent G, Seifert H, Davin S, Stauffer P, Vandenbark A, Karstens L, Asquith M, Offner H. Journal of Neuroimmunology. 2017; 310:51-59. PMID: 28778445
- Does the urinary microbiome play a role in urgency urinary incontinence and its severity? Karstens L, Asquith M, Davin S, Stauffer P, Fair D, Gregory WT, Rosenbaum J, McWeeney S, Nardos R. Frontiers in Cellular and Infection Biology. 2016 Jul 27;6:78.PMID: 27512653
- Gut Microbial Alterations Associated With Protection From Autoimmune Uveitis. Nakamura YK, Metea C, Karstens L, Asquith M, Gruner H, Moscibrocki C, Lee I, Brislawn CJ, Jansson JK, Rosenbaum JT, Lin P. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3747-58. PMID: 27415793
- Abnormal Functional Connectivity in Women with Urgency Urinary Incontinence: Can We Predict Disease Presence and Severity in Individual Women Using Rs-fcMRI? Nardos R, Karstens L, Carpenter S, Aykes K, Krisky C, Stevens C, Fair D. Neurourology and Urodynamics. 2016; 35(5):563-73. PMID:25933352
- Medications are associated with falls in people with MS: A prospective cohort study. Cameron MH, Karstens L, Hoang P, Bourdette D, Lord S. International Journal of MS Care. 2015; 17(5): 207-214. PMID: 26472941
- Metabolomics approach to human brain spectroscopy identifies associations between clinical features and the frontal lobe metabolome in multiple sclerosis. LK Vingara, HJ Yu, M Wagshul, D Searafin, C Christodoulou, I Pelzcer, L Krupp, M Maleti?–Savati? NeuroImage 2013; 82: 586-594. PMID: 23751863
- Optimized pre-processing of UPLC-MS metabolic profiles for improved information recovery. K Veselkov,* LK Vingara,* P Masson, S Robinette, E Want, J Li, B Walther, C Boursier, R Barton, T Ebbels, I Pelczer, J Lindon, E Holmes, J Nicholson. Anal. Chem, 2011; 83, 5864–5872. PMID: 21526840 *Joint first authors
Publications
A cost and community perspective on the barriers to microbiome data reuse
Frontiers in BioinformaticsBody mass index and benign prostatic hyperplasia correlate with urinary microbiome diversity and lower urinary tract symptoms in men
Communications MedicineGut microbiome changes with micronutrient supplementation in children with attention–deficit/hyperactivity disorder
Gut MicrobesCharacterization of pediatric urinary microbiome at species-level resolution indicates variation due to sex, age, and urologic history
Journal of Pediatric UrologyUrinary microbiome community types associated with urinary incontinence severity in women
American journal of obstetrics and gynecologyA diet rich in fermentable fiber promotes robust changes in the intestinal microbiota, mitigates intestinal permeability, and attenuates autoimmune uveitis
Scientific ReportsAssociation between Gut Microbiota and Breast Cancer
NutrientsAntimetabolite Drugs Exhibit Distinctive Immunomodulatory Mechanisms and Effects on the Intestinal Microbiota in Experimental Autoimmune Uveitis
Investigative Ophthalmology and Visual ScienceAxial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota
Frontiers in immunologymicroshades
Microbiology Resource AnnouncementsNetwork-Based Differences in the Vaginal and Bladder Microbial Communities Between Women With and Without Urgency Urinary Incontinence
Frontiers in Cellular and Infection MicrobiologyOral microbiome diversity
Molecular Oral MicrobiologyThe Impact of Local Estrogen on the Urogenital Microbiome in Genitourinary Syndrome of Menopause
Female Pelvic Medicine and Reconstructive SurgeryUpdating Urinary Microbiome Analyses to Enhance Biologic Interpretation
Frontiers in Cellular and Infection MicrobiologyBenchmarking DNA isolation kits used in analyses of the urinary microbiome
Scientific ReportsForming consensus to advance urobiome research
mSystemsSpecies-level resolution of female bladder microbiota from 16s rrna amplicon sequencing
mSystemsThe Urinary Microbiome in Postmenopausal Women with Recurrent Urinary Tract Infections
Journal of UrologyAlpha-glucosidase inhibitors alter gut microbiota and ameliorate collagen-induced arthritis
Frontiers in PharmacologyControlling for contaminants in low-biomass 16S rRNA gene sequencing experiments
mSystemsDisruption of intestinal homeostasis and intestinal microbiota during experimental autoimmune uveitis
Investigative Ophthalmology and Visual ScienceHLA Alleles Associated With Risk of Ankylosing Spondylitis and Rheumatoid Arthritis Influence the Gut Microbiome
Arthritis and RheumatologyPerformance of microbiome sequence inference methods in environments with varying biomass
mSystems